UMUC3 SMAD/TGFbeta Reporter (Luc) cells are derived from the human UMUC3 urinary bladder carcinoma cell line by stably integration of a SMAD/TGFbeta firefly luciferase reporter construct. UMUC3 cells are a powerful tool in bladder cancer research, providing insights into tumor biology, metastasis, and drug resistance, as well as serving as a model for testing new therapeutic strategies for bladder cancer treatment. UMUC3 SMAD/TGFbeta Reporter (Luc) cells stably express firefly luciferase under the control of the SMAD/TGFbeta response elements, can be used for monitoring the activity of TGF?/SMAD signaling pathway.