THP-1/Luciferase cells are derived from the human monocytic THP-1 cell line by stably integration of a constitutive Firefly luciferase expression construct. The THP-1 cell line is widely used to study the function of monocytes and macrophages, as well as in leukemia research. THP-1/Luciferase cells stably express firefly luciferase, can be used for in vitro assays and in vivo imaging.