SUP-B15/Cre cells are derived from the human B-cell acute lymphoblastic leukemia (ALL) cell line SUP-B15 by stably integration of a constitutive Cre recombinase stably expression construct. SUP-B15 is used in research to investigate the biology of B-cell leukemia, including cellular signaling pathways, mechanisms of drug resistance, and the effects of potential anti-leukemic drugs. SUP-B15/Cre cells stably express a nuclear localized Cre recombinase.