SU-DHL-1/iRFP cells are derived from the human histiocytic lymphoma SU-DHL-1 cell line by stably integration of a constitutive miRFP670 stably expression construct. SU-DHL-1 cell line has a high proliferation rate and is used to study various aspects of lymphoma biology, including the mechanisms of tumor growth and the effects of treatments. SU-DHL-1/iRFP cells stably express miRFP670, can be used for in vitro assays and in vivo imaging.