SK-OV-3 SMAD/TGFbeta Reporter (Luc) cells are derived from the human ovarian cancer SK-OV-3 cell line by stably integration of a SMAD/TGFbeta firefly luciferase reporter construct. SK-OV-3 cell line has been widely used in Investigating cancer biology, studying tumor microenvironment, and testing new drugs particularly for chemotherapeutics and targeted therapies. SK-OV-3 SMAD/TGFbeta Reporter (Luc) cells stably express firefly luciferase under the control of the SMAD/TGFbeta response elements, can be used for monitoring the activity of TGF?/SMAD signaling pathway.