RPMI-1788/iRFP cells are derived from the human B lymphocyte RPMI-1788 cell line by stably integration of a constitutive miRFP670 stably expression construct. RPMI-1788 cells have been used in cancer research and drug development. RPMI-1788/iRFP cells stably express miRFP670, can be used for in vitro assays and in vivo imaging.