RENCA/STAT5 Reporter (GFP) cells are derived from the mouse renal adenocarcinoma RENCA cell line by stably integration of a STAT5 GFP reporter construct. The RENCA cell line is a useful model for understanding the biology of renal cell carcinoma and testing therapeutic strategies. RENCA/STAT5 Reporter (GFP) cells stably express GFP under the control of the STAT5 response elements, can be used for monitoring the activity of STAT5 signaling pathway.