RENCA/STAT3 Reporter (Luc) cells are derived from the mouse renal adenocarcinoma RENCA cell line by stably integration of a STAT3 firefly luciferase reporter construct. The RENCA cell line is a useful model for understanding the biology of renal cell carcinoma and testing therapeutic strategies. RENCA/STAT3 Reporter (Luc) cells stably express firefly luciferase under the control of the STAT3 response elements, can be used for monitoring the activity of STAT3 signaling pathway.