Raw264.7 SMAD/TGFbeta Reporter (Luc) cells are derived from the mouse macrophage cell line Raw264.7 by stably integration of a SMAD/TGFbeta firefly luciferase reporter construct. Raw264.7 cells have been used as a model for studying the response of inflammatory molecules to various stimuli and evaluating the effects of anti-inflammatory drugs. Raw264.7 SMAD/TGFbeta Reporter (Luc) cells stably express firefly luciferase under the control of the SMAD/TGFbeta response elements, can be used for monitoring the activity of TGFβ/SMAD signaling pathway.