Ramos/STAT3 Reporter (Luc) cells are derived from the human B lymphocyte cell line Ramos by stably integration of a STAT3 firefly luciferase reporter construct. Ramos cell line was generated from a human Burkitt′s lymphoma which does not possess the EBV genome, has been widely used in cancer research, virus study and drug development.  Ramos cells express CD19, CD20, and other B-cell markers, making them a useful model for B-cell studies and test the efficacy of monoclonal antibodies and CAR T-cell therapies targeting B-cell malignancies. Ramos/STAT3 Reporter (Luc) cells stably express firefly luciferase under the control of the STAT3 response elements, can be used for monitoring the activity of STAT3 signaling pathway.