NCI-H929/STAT3 Reporter (Luc) cells are derived from the human B lymphocyte NCI-H929 cell line by stably integration of a STAT3 firefly luciferase reporter construct. NCI-H929 cells stably express B cell maturation antigen (BCMA)-a novel treatment target for multiple myeloma (MM), and have been widely used in cancer research and drug development. NCI-H929/STAT3 Reporter (Luc) cells stably express firefly luciferase under the control of the STAT3 response elements, can be used for monitoring the activity of STAT3 signaling pathway.