NCI-H292 SMAD/TGFbeta Reporter (Luc) cells are derived from the human NCI-H292 lung carcinoma cell line by stably integration of a SMAD/TGFbeta firefly luciferase reporter construct. NCI-H292 cell line has been used for investigating cellular responses to different treatments, studying the mechanisms of cancer progression, and testing potential therapeutic agents.  NCI-H292 SMAD/TGFbeta Reporter (Luc) cells stably express firefly luciferase under the control of the SMAD/TGFbeta response elements, can be used for monitoring the activity of TGF?/SMAD signaling pathway.