NCI-H1437 SMAD/TGFbeta Reporter (Luc) cells are derived from the human NCI-H1437 lung carcinoma cell line by stably integration of a SMAD/TGFbeta firefly luciferase reporter construct. NCI-H1437 cell line was derived from a patient with non-small cell lung carcinoma (NSCLC), and is used extensively in cancer research, particularly for studies focused on lung cancer biology, drug development, and therapeutic responses. NCI-H1437 SMAD/TGFbeta Reporter (Luc) cells stably express firefly luciferase under the control of the SMAD/TGFbeta response elements, can be used for monitoring the activity of TGF?/SMAD signaling pathway.