NCI-H1437/RFP-Luciferase cells are derived from the human NCI-H1437 lung carcinoma cell line by stably integration of a constitutive RFP-Firefly luciferase stably expression construct. NCI-H1437 cell line was derived from a patient with non-small cell lung carcinoma (NSCLC), and is used extensively in cancer research, particularly for studies focused on lung cancer biology, drug development, and therapeutic responses.  NCI-H1437/RFP-Luciferse cells stably stably express RFP and Firefly luciferase, can be used for in vitro assays and in vivo imaging.