NAMALWA/RFP-Luciferase cells are derived from the human B lymphocyte cell line NAMALWA by stably integration of a constitutive RFP-Firefly luciferase stably expression construct. NAMALWA cell line was derived from a patient with Burkitt's lymphoma. It is commonly used in studies related to cancer biology, immunology, and virology. NAMALWA/RFP-Luciferse cells stably stably express RFP and Firefly luciferase, can be used for in vitro assays and in vivo imaging.