NALM6/Cre cells are derived from the human precursor B cell lymphoblast cell line NALM6 by stably integration of a constitutive Cre recombinase stably expression construct. NALM6 cells stably express CD19, are ideal for testing CAR T cell or other immunotherapies. NALM6/Cre cells stably express a nuclear localized Cre recombinase.