MV4-11/STAT3 Reporter (Luc) cells are derived from the human MV4-11 macrophage cell line by stably integration of a STAT3 firefly luciferase reporter construct. MV4-11 cell line was generated from biphenotypic B myelomonocytic leukemia, has been widely used in cancer research and drug development. MV4-11/STAT3 Reporter (Luc) cells stably express firefly luciferase under the control of the STAT3 response elements, can be used for monitoring the activity of STAT3 signaling pathway.