Mino/RFP-Luciferase cells are derived from the human mantle cell lymphoma (MCL) Mino cell line by stably integration of a constitutive RFP-Firefly luciferase stably expression construct. Mino cell line is a valuable model to study mantle cell lymphoma cancer biology and to test new drugs and therapeutic approaches for treating mantle cell lymphoma. Mino/RFP-Luciferase cells stably stably express RFP and Firefly luciferase, can be used for in vitro assays and in vivo imaging.