LNCaP SMAD/TGFbeta Reporter (Luc) cells are derived from the human prostate cancer LNCaP cell line by stably integration of a SMAD/TGFbeta firefly luciferase reporter construct. LNCaP cells are androgen-sensitive, making them valuable for studying prostate cancer biology and testing potential treatments related to hormone regulation. LNCaP SMAD/TGFbeta Reporter (Luc) cells stably express firefly luciferase under the control of the SMAD/TGFbeta response elements, can be used for monitoring the activity of TGFβ/SMAD signaling pathway.