Lentiviral human WRNIP1 sgRNA gene knockout kit (25)
Lentiviral particles for a set of three sgRNAs mixture (10^8 TU/ml, 25 ul), and a pair of Indel screening PCR primers (100 reactions)
$499.00
HKO-625854-100
Lentiviral human WRNIP1 sgRNA gene knockout kit (100)
Lentiviral particles for a set of three sgRNAs mixture (10^8 TU/ml, 100 ul), and a pair of Indel screening PCR primers (200 reactions)
$890.00
HKO-625854-10ug
Lentiviral human WRNIP1 sgRNA gene knockout kit (plasmid)
Lentiviral plasmids for a set of three sgRNAs (10ug each), and a pair of Indel screening PCR primers (200 reactions)
$890.00
Product Details
Target gene information
Gene symbol
WRNIP1
Synonyms
bA420G6.2 CFAP93 FAP93 WHIP
Species
HUMAN
Gene ID
56897
Summary
Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012].
