Lentiviral particles or plasmids for 3 unique target specific shRNA and 1 scramble shRNA, RT-PCR primer mix for target specific gene and a housekeeping gene
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the human synapsin 1 gene promoter, 25 ul each, functional titer of 1x10^8 TU/ml
$1,190.00
HSH-918974-100
Lentiviral human PTRH2 shRNA (Synapsin) (100)
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the human synapsin 1 gene promoter, 4x25 ul each, functional titer of 1x10^8 TU/ml
$2,690.00
HSH-918974-10ug
Lentiviral human PTRH2 shRNA (Synapsin) plasmid
Lentiviral constructs for 3 unique target specific shRNA and 1 scramble shRNA driven by the human synapsin 1 gene promoter, 10 ug each
$1,490.00
HSH-918974-25GFP
Lentiviral human PTRH2 shRNA (Synapsin,GFP) (25)
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the human synapsin 1 gene promoter, with a GFP reporter, 25 ul each, functional titer of 1x10^8 TU/ml
$1,190.00
HSH-918974-100GFP
Lentiviral human PTRH2 shRNA (Synapsin,GFP) (100)
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the human synapsin 1 gene promoter, with a GFP reporter, 4x25 ul each, functional titer of 1x10^8 TU/ml
$2,690.00
HSH-918974-10ugGFP
Lentiviral human PTRH2 shRNA (Synapsin,GFP) plasmid
Lentiviral constructs for 3 unique target specific shRNA and 1 scramble shRNA driven by the human synapsin 1 gene promoter, with a GFP reporter, 10 ug each
$1,490.00
HSH-918974-25RFP
Lentiviral human PTRH2 shRNA (Synapsin,RFP) (25)
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the human synapsin 1 gene promoter, with a RFP reporter, 25 ul each, functional titer of 1x10^8 TU/ml
$1,190.00
HSH-918974-100RFP
Lentiviral human PTRH2 shRNA (Synapsin,RFP) (100)
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the human synapsin 1 gene promoter, with a RFP reporter, 4x25 ul each, functional titer of 1x10^8 TU/ml
$2,690.00
HSH-918974-10ugRFP
Lentiviral human PTRH2 shRNA (Synapsin,RFP) plasmid
Lentiviral constructs for 3 unique target specific shRNA and 1 scramble shRNA driven by the human synapsin 1 gene promoter, with a RFP reporter, 10 ug each
$1,490.00
HSH-918974-25iRFP
Lentiviral human PTRH2 shRNA (Synapsin,iRFP) (25)
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the human synapsin 1 gene promoter, with a miRFP670 reporter, 25 ul each, functional titer of 1x10^8 TU/ml
$1,190.00
HSH-918974-100iRFP
Lentiviral human PTRH2 shRNA (Synapsin,iRFP) (100)
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the human synapsin 1 gene promoter, with a miRFP670 reporter, 4x25 ul each, functional titer of 1x10^8 TU/ml
$2,690.00
HSH-918974-10ugiRFP
Lentiviral human PTRH2 shRNA (Synapsin,iRFP) plasmid
Lentiviral constructs for 3 unique target specific shRNA and 1 scramble shRNA driven by the human synapsin 1 gene promoter, with a miRFP670 reporter, 10 ug each
$1,490.00
Product Details
Target gene information
Gene symbol
PTRH2
Synonyms
BIT1 CFAP37 CGI-147 IMNEPD PTH PTH 2 PTH2
Species
human
Gene ID
51651
Summary
The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos. After loss of cell attachment to the ECM, this protein is phosphorylated, is released from the mitochondria into the cytosol, and promotes caspase-independent apoptosis through interactions with transcriptional regulators. This gene has been implicated in the development and progression of tumors, and mutations in this gene have been associated with an infantile multisystem neurologic, endocrine, and pancreatic disease (INMEPD) characterized by intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency (PMID: 25574476). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015].
