Lentiviral particles or plasmids for 3 unique target specific shRNA and 1 scramble shRNA, RT-PCR primer mix for target specific gene and a housekeeping gene
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the CMV promoter, 25 ul each, functional titer of 1x10^8 TU/ml
$890.00
HSH-527678-100
Lentiviral human PKD1 shRNA (CMV) (100)
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the CMV promoter, 4x25 ul each, functional titer of 1x10^8 TU/ml
$1,980.00
HSH-527678-10ug
Lentiviral human PKD1 shRNA (CMV) plasmid
Lentiviral constructs for 3 unique target specific shRNA and 1 scramble shRNA driven by the CMV promoter, 10 ug each
$1,190.00
Product Details
Target gene information
Gene symbol
PKD1
Synonyms
PBP Pc-1 PC1 TRPP1
Species
human
Gene ID
5310
Summary
This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described. [provided by RefSeq, Oct 2008].
