Lentiviral particles or plasmids for 3 unique target specific shRNA and 1 scramble shRNA, RT-PCR primer mix for target specific gene and a housekeeping gene
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the tet-inducible promoter, 25 ul each, functional titer of 1x10^8 TU/ml
$1,190.00
HSH-814733-100
Lentiviral human PDHX shRNA (tet) (100)
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the tet-inducible promoter, 4x25 ul each, functional titer of 1x10^8 TU/ml
$2,690.00
HSH-814733-10ug
Lentiviral human PDHX shRNA (tet) plasmid
Lentiviral constructs for 3 unique target specific shRNA and 1 scramble shRNA driven by the tet-inducible promoter, 10 ug each
$1,490.00
HSH-814733-25GFP
Lentiviral human PDHX shRNA (tet,GFP) (25)
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the tet-inducible promoter, with a GFP reporter, 25 ul each, functional titer of 1x10^8 TU/ml
$1,190.00
HSH-814733-100GFP
Lentiviral human PDHX shRNA (tet,GFP) (100)
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the tet-inducible promoter, with a GFP reporter, 4x25 ul each, functional titer of 1x10^8 TU/ml
$2,690.00
HSH-814733-10ugGFP
Lentiviral human PDHX shRNA (tet,GFP) plasmid
Lentiviral constructs for 3 unique target specific shRNA and 1 scramble shRNA driven by the tet-inducible promoter, with a GFP reporter, 10 ug each
$1,490.00
HSH-814733-25RFP
Lentiviral human PDHX shRNA (tet,RFP) (25)
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the tet-inducible promoter, with a RFP reporter, 25 ul each, functional titer of 1x10^8 TU/ml
$1,190.00
HSH-814733-100RFP
Lentiviral human PDHX shRNA (tet,RFP) (100)
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the tet-inducible promoter, with a RFP reporter, 4x25 ul each, functional titer of 1x10^8 TU/ml
$2,690.00
HSH-814733-10ugRFP
Lentiviral human PDHX shRNA (tet,RFP) plasmid
Lentiviral constructs for 3 unique target specific shRNA and 1 scramble shRNA driven by the tet-inducible promoter, with a RFP reporter, 10 ug each
$1,490.00
HSH-814733-25iRFP
Lentiviral human PDHX shRNA (tet,iRFP) (25)
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the tet-inducible promoter, with a miRFP670 reporter, 25 ul each, functional titer of 1x10^8 TU/ml
$1,190.00
HSH-814733-100iRFP
Lentiviral human PDHX shRNA (tet,iRFP) (100)
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the tet-inducible promoter, with a miRFP670 reporter, 4x25 ul each, functional titer of 1x10^8 TU/ml
$2,690.00
HSH-814733-10ugiRFP
Lentiviral human PDHX shRNA (tet,iRFP) plasmid
Lentiviral constructs for 3 unique target specific shRNA and 1 scramble shRNA driven by the tet-inducible promoter, with a miRFP670 reporter, 10 ug each
$1,490.00
Product Details
Target gene information
Gene symbol
PDHX
Synonyms
DLDBP E3BP OPDX PDHXD PDX1 proX
Species
human
Gene ID
8050
Summary
The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit; also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009].
