Lentiviral human KIF14 sgRNA gene knockout kit (25)
Lentiviral particles for a set of three sgRNAs mixture (10^8 TU/ml, 25 ul), and a pair of Indel screening PCR primers (100 reactions)
$499.00
HKO-614610-100
Lentiviral human KIF14 sgRNA gene knockout kit (100)
Lentiviral particles for a set of three sgRNAs mixture (10^8 TU/ml, 100 ul), and a pair of Indel screening PCR primers (200 reactions)
$890.00
HKO-614610-10ug
Lentiviral human KIF14 sgRNA gene knockout kit (plasmid)
Lentiviral plasmids for a set of three sgRNAs (10ug each), and a pair of Indel screening PCR primers (200 reactions)
$890.00
Product Details
Target gene information
Gene symbol
KIF14
Synonyms
MCPH20 MKS12
Species
HUMAN
Gene ID
9928
Summary
This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015].
