Lentiviral particles or plasmids for 3 unique target specific shRNA and 1 scramble shRNA, RT-PCR primer mix for target specific gene and a housekeeping gene
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the tet-inducible promoter, 25 ul each, functional titer of 1x10^8 TU/ml
$1,190.00
HSH-818315-100
Lentiviral human CDK5R1 shRNA (tet) (100)
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the tet-inducible promoter, 4x25 ul each, functional titer of 1x10^8 TU/ml
$2,690.00
HSH-818315-10ug
Lentiviral human CDK5R1 shRNA (tet) plasmid
Lentiviral constructs for 3 unique target specific shRNA and 1 scramble shRNA driven by the tet-inducible promoter, 10 ug each
$1,490.00
HSH-818315-25GFP
Lentiviral human CDK5R1 shRNA (tet,GFP) (25)
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the tet-inducible promoter, with a GFP reporter, 25 ul each, functional titer of 1x10^8 TU/ml
$1,190.00
HSH-818315-100GFP
Lentiviral human CDK5R1 shRNA (tet,GFP) (100)
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the tet-inducible promoter, with a GFP reporter, 4x25 ul each, functional titer of 1x10^8 TU/ml
$2,690.00
HSH-818315-10ugGFP
Lentiviral human CDK5R1 shRNA (tet,GFP) plasmid
Lentiviral constructs for 3 unique target specific shRNA and 1 scramble shRNA driven by the tet-inducible promoter, with a GFP reporter, 10 ug each
$1,490.00
HSH-818315-25RFP
Lentiviral human CDK5R1 shRNA (tet,RFP) (25)
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the tet-inducible promoter, with a RFP reporter, 25 ul each, functional titer of 1x10^8 TU/ml
$1,190.00
HSH-818315-100RFP
Lentiviral human CDK5R1 shRNA (tet,RFP) (100)
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the tet-inducible promoter, with a RFP reporter, 4x25 ul each, functional titer of 1x10^8 TU/ml
$2,690.00
HSH-818315-10ugRFP
Lentiviral human CDK5R1 shRNA (tet,RFP) plasmid
Lentiviral constructs for 3 unique target specific shRNA and 1 scramble shRNA driven by the tet-inducible promoter, with a RFP reporter, 10 ug each
$1,490.00
HSH-818315-25iRFP
Lentiviral human CDK5R1 shRNA (tet,iRFP) (25)
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the tet-inducible promoter, with a miRFP670 reporter, 25 ul each, functional titer of 1x10^8 TU/ml
$1,190.00
HSH-818315-100iRFP
Lentiviral human CDK5R1 shRNA (tet,iRFP) (100)
Lentiviral particles for 3 unique target specific shRNA and 1 scramble shRNA driven by the tet-inducible promoter, with a miRFP670 reporter, 4x25 ul each, functional titer of 1x10^8 TU/ml
$2,690.00
HSH-818315-10ugiRFP
Lentiviral human CDK5R1 shRNA (tet,iRFP) plasmid
Lentiviral constructs for 3 unique target specific shRNA and 1 scramble shRNA driven by the tet-inducible promoter, with a miRFP670 reporter, 10 ug each
$1,490.00
Product Details
Target gene information
Gene symbol
CDK5R1
Synonyms
CDK5P35 CDK5R NCK5A p23 p25 p35 p35nck5a
Species
human
Gene ID
8851
Summary
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008].
