KLN205/Cre cells are derived from the murine lung squamous cell carcinoma cell line KLN205 by stably integration of a constitutive Cre recombinase stably expression construct. KLN205 cell line is a well established model for cancer research, particularly for studying lung cancer mechanisms and potential therapies. KLN205/Cre cells stably express a nuclear localized Cre recombinase.