IM-9/iRFP cells are derived from the human B lymphoblast IM-9 cell line by stably integration of a constitutive miRFP670 stably expression construct. IM-9 cells are widely used in research related to hematological malignancies and multiple myeloma, as well as drug development. IM-9/iRFP cells stably express miRFP670, can be used for in vitro assays and in vivo imaging.