HL-60/NF-kB Reporter (Luc) cells are derived from the human leukemia HL-60 cell line by stably integration of a NF-kB firefly luciferase reporter construct. HL-60 cells have been used in cancer research and drug development. HL-60/NF-kB Reporter (Luc) cells stably express firefly luciferase under the control of the NF-kB response elements, can be used for monitoring the activity of NF-kB signaling pathway.