Hep3B/Cre cells are derived from the human Hep3B Hepatocellular carcinoma cell line by stably integration of a constitutive Cre recombinase stably expression construct. The Hep3B cell line has been widely used in cancer research, particularly in studies related to liver cancer, and drug screening. Hep3B/Cre cells stably express a nuclear localized Cre recombinase.