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$1,980.00

HEK293T/ACE2 stable cell line

Catalog number
CL-1477
Description
HEK293T/ACE2 cells are derived from the human immortalized embryonic kidney cell line HEK 293 by stably integration of a constitutive human angiotensin-converting enzyme 2 (ACE2) expression construct. ACE2 is a receptor on the surface of cells that plays a crucial role in the entry of the SARS-CoV-2 virus into cells and causing COVID-19 infection. HEK293T/ACE2 cells stably express ACE2, can be used for studying various aspects of viral infection and developing potential therapeutic interventions such as testing antiviral compounds or vaccines.
HEK293T/ACE2 stable cell line
Overview Product Details Resources

Overview

Human Angiotensin converting enzyme 2 (ACE2) is the entry point for COVID-19 (SARS-CoV-2) due to its interaction with the coronavirus Spike protein. To accelerate your COVID-19 research, we provide premade HEK293T/ACE2 stable cell line.  HEK293T/ACE2 stable cell line is generated by transducing HEK293T cells with our premade ACE2 lentivirus (CMV, Puro). Combined with SARS-CoV-2 spike protein pseudotyped GFP, RFP, firefly luciferase or GFP-Firefly luciferase lentiviruses, it provides a model for studying COVID-19 entry of cells and screening of drugs to block COVID-19 entry.

Features:

  • Validated for ACE2 expression and COVID-19 spike protein- pseudotyped lentivirus entry
  • In vitro model for screening antibody or inhibitors to block COVID-19 infection

Product Details

Package Size 2 x 10^6 cells
Parental cell line HEK293T cells
Transgenic gene Human ACE2
Mammalian selection Puromycin
Biosafety level 2
Storage Liquid nitrogen
Availability In stock
Shipping condition dry ice

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