HEK 293/STAT3 Reporter (Luc) cells are derived from the human immortalized embryonic kidney cell line HEK 293 by stably integration of a STAT3 firefly luciferase reporter construct. HEK 293 cells have been widely used in cell biology research because of their reliable growth and propensity for transfection. HEK 293/STAT3 Reporter (Luc) cells stably express firefly luciferase under the control of the STAT3 response elements, can be used for monitoring the activity of STAT3 signaling pathway.