Calu-3/NF-kB Reporter (Luc) cells are derived from the human Calu-3 lung carcinoma cell line by stably integration of a NF-kB firefly luciferase reporter construct. Calu-3 cell line has been widely used in cancer research, drug development and as respiratory models in preclinical applications. Calu-3/NF-kB Reporter (Luc) cells stably express firefly luciferase under the control of the NF-kB response elements, can be used for monitoring the activity of NF-kB signaling pathway.