C4-2/STAT3 Reporter (Luc) cells are derived from the human prostate cancer C4-2 cell line by stably integration of a STAT3 firefly luciferase reporter construct. The C4-2 cell line is notable for its ability to metastasize to lymph nodes and bone, making it a valuable model for studying advanced prostate cancer and metastasis. C4-2/STAT3 Reporter (Luc) cells stably express firefly luciferase under the control of the STAT3 response elements, can be used for monitoring the activity of STAT3 signaling pathway.