Oct 16, 2020
COVID-19 is an acute respiratory disease caused by novel coronavirus SARS-CoV-2. It has cost million people’s lives. Scientists around the world are working to battle this pandemic by developing new therapeutics and vaccines. FenicsBIO is devoted to support Covid-19 research by continuing developing and launching new products to meet Covid-19 research needs. With FenicsBIO’s expertise on molecular biology, virology and cell biology, we have developed series of products to support Covid-19 research, and more products are coming. If you do not see the products you need, please contact us and we will do our best to meet your needs.
Our available products include:
1. ACE2 related products
Human Angiotensin converting enzyme 2 (ACE2) is a membrane protein found on the surface of cells in the lung, arteries, heart, kidney, and intestine. ACE2 is the entry point for COVID-19 (SARS-CoV-2) due to its interaction with the coronavirus Spike protein. Our ACE2 related products include:
2. SARS-CoV-2 spike protein pseudotyped lentiviruses
SARS-CoV-2 spike pseudotyped lentiviruses have the SARS-CoV-2 spike (S) protein instead of the commonly used VSV-G as the envelop. The SARS-CoV-2 spike (S) protein pseudotyped lentiviruses are valuable tools for studying the mechanism of virus-receptor interaction and developing therapeutic drugs for Convid-19 in biosafety 2 conditions. Please check these related products:
- SARS-CoV-2 spike protein pseudotyped GFP-Luciferase lentivirus
- SARS-CoV-2 spike protein pseudotyped firefly luciferase lentivirus
- SARS-CoV-2 spike protein pseudotyped GFP lentivirus
- SARS-CoV-2 spike protein pseudotyped RFP lentivirus
- Lenti-HT SARS-CoV-2 spike pseudotyped lentivirus packaging system
Check back for new Convid-19 products in our pipeline:
1. Human TMPRSS2 related products
The serine protease TMPRSS2 plays a crucial role in SARS-CoV-2 pathogenesis by cleaving the viral S glycoprotein and facilitating viral activation. It has been reported a TMPRSS2 inhibitor approved for clinical use blocked SARS-CoV-2 entry.
FenicsBIO is developing a series of TMPRSS2 products:
- Human TMPRSS2 lentiviral expression vector
- Human TMPRSS2 lentivirus
- HEK293T/ TMPRSS2 stable cell line
- HEK293T/ ACE2 and TMPRSS2 stable cell line
- TMPRSS2 shRNA lentiviral plasmids and virus
- TMPRSS2 sgRNA lentiviral plasmids and virus
2. Human Neuropilin-1 related products
Neuropilin-1 (NRP1), has recently been reported to significantly potentiate SARS-CoV-2 infectivity by binding to furin-cleaved SARS-CoV-2 Spike (S) protein. Blocking this interaction using RNAi, selective inhibitors or an antibody against NRP1 reduced SARS-CoV-2 entry and infectivity, making NRP1 a potential therapeutic target.
The Neuropilin-1 related products that are developing at FenicsBIO include:
- Human Neuropilin-1 lentiviral expressing vector
- Human Neuropilin-1 lentivirus
- Human Neuropilin-1 shRNA lentiviral plasmids and virus
- Human Neuropilin-1 sgRNA lentiviral plasmids and virus
References
- C. Walls et al. (2020). Structure, Function, and Antigenicity of the SARSCoV-2 Spike Glycoprotein. Cell 180, 281–292
- Hoffmann et al. (2020). SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell 181, 271–280
- Cantuti-Castelvetri et al. (2020). Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science 10.1126/science.abd2985 (2020).
- L. Daly et al. (2020) Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science 10.1126/science.abd3072 (2020)